There are a few chondrocyte-like cells in the nucleus pulposus. The nucleus pulposus is made from randomly arranged collagen fibers and radially organized elastin fibers surrounded in a highly hydrated aggrecan-containing gel. The cells in the outer region of the annulus fibrosus are fibroblast-like cells which are disposed parallel to the collagen fibers, while those in the inner annulus fibrosus are chondrocyte-like cells. The endplates serve as an interface between the disc and the vertebrae, they cover the upper and lower level of the annulus fibrosus and the nucleus pulposus. The annulus fibrosus (AF), an outer ring of fibrous tissue that encloses the nucleus pulposus.The nucleus pulposus (NP), a gelatinous inner part.The intervertebral disc (IVD) is the principal joint between two vertebrae in the vertebral column.Įach IVD is composed of three structures: ĭiscogenic pain is pain arising from stimulation of pain sensitive afferents within the annulus fibrosus and is a separate condition from disc herniation with associated radiculopathy. A degenerated intervertebral disk can release nociceptive molecules and growth factors which result in nerve ingrowth into the disc. Pain can be related to different types of pain which come from muscles, bones, vertebral joints other than the intervertebral disc or other structures in the spine. Of all the patients who are dealing with low back pain, it appears that in approximately 28 to 40% of these cases, pain is caused by a discogenic affliction. ![]() Detailed structure of the intervertebral disc (adapted from Bogduk 2005)
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